Lego DNA Game

            This game is whimsical and a lot of fun. At the same time, it teaches the concept that physical traits are encoded by genes that are found on chromosomes.

Contents:

         10 bags, each with the following Lego pieces
         7- 8 piece
         8- 4 piece (6 for the game + 2 extras)
         1 bag of Legos with extra pieces

Goal: 

        Create a DNA strand with 6 bases (2 amino acids) and use the “secret decoder” to uncover the participant’s sex, eye color and hair color.

Play:

        1) Hand out one bag to each student.
        2) Instruct them to build a DNA strand by connecting the 8-piece Legos with the 4-piece Legos as shown below: (Tell them there are 2 extras)
 
 
 

                    

 

        3) Explain how it takes 3 bases to code for an amino acid—the building blocks of proteins. Each gene codes for a string of amino acids that make a protein. However, sometimes a change in just one of those amino acids can change a trait. For simplicity, all of our traits are going to be determined by a single amino acid. In this case, we are building proteins for eye color and hair color (Or you can choose whatever characteristic or feature you’d like).  The first 3 code for eye color and the second 3 for hair color.
           Once they have built their DNA strand, you help them “decode” it.  It is the 1st of the 3 that determines the characteristic as shown:

Red backbone: female
Blue Backbone: male

                          Eye Color       Hair Color
Red first:             brown             red
Blue first:            blue                black
White first:          albino             albino
Yellow first:        green              blonde

** Note:

        There is one black 4-piece. This is a mutation.  If black is the first Lego in the eye color gene, then the participant’s eyes are PURPLE!!  If it is the first Lego in the hair color gene, the participant’s hair is PURPLE!!
 

Second round

                              Height           Skin covering
Red first:                 tall                feathers
Blue first:                short             scales
White first:              medium        fur
Yellow first:            8 feet           slime

** Note:

        There is one black 4-piece. This is a mutation.  If black is the first Lego in the eye color gene, then the participant’s height is 10 inches!!  If it is the first Lego in the hair color gene, the participant’s skin is PURPLE!!