mostrecentpubs

Recent Publications:
Huntoon KM, Wang Y, Eppolito CA, Barbour KW, Berger FG, Shrikant PA, Baumann H. The acute phase protein haptoglobin regulates host immunity. J Leukoc Biol. 2008 Apr 24. [Epub ahead of print] Misra S, Obeid LM, Hannun YA, Minamisawa S, Berger FG, Markwald RR, Toole BP, Ghatak S. Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. J Biol Chem. 2008 May 23;283(21):14335-44. Epub 2008 Mar 7. Kwon IK, Schoenlein PV, Delk J, Liu K, Thangaraju M, Dulin NO, Ganapathy V, Berger FG, Browning DD. Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis. Cancer. 2008 Apr 1;112(7):1462-70. Baltgalvis KA, Berger FG, Peña MM, Davis JM, Carson JA. Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps. J Appl Physiol. 2008 Apr;104(4):1137-43. Epub 2008 Jan 31. Baltgalvis KA, Berger FG, Pena MM, Davis JM, Muga SJ, Carson JA. Interleukin-6 and cachexia in ApcMin/+ mice. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R393-401. Epub 2007 Dec 5. Barbour KW and Berger FG. Cell Death in response to antimetabolites directed at thymidylate synthase. Cancer Chemotherapy and Pharmacolgy. 2007. Cancer Chemother Pharmacol. 2007 Mar 30; [Epub ahead of print]. Berger FG and Berger SH. Thymidylate Synthase as a Chemotherapeutic Drug Target: Where Are We after Fifty Years? Cancer Biol Ther. 2006 Sep 13;5(9):1238-1241. You S, Ohmori M, Pena MM, Nassri B, Quiton J, Al-Assad ZA, Liu L, Wood PA, Berger SH, Liu Z, Wyatt MD, Price RL, Berger FG, Hrushesky WJ. Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol. 2006 Jun;87(3):227-36. Pena MM, Xing YY, Koli S, Berger FG. Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase. Biochem J. 2005 Feb 15;394(Pt 1):355-63. Mehl KA, Davis JM, Berger FG, Carson JA. Myofiber degeneration/regeneration is induced in the cachectic ApcMin/+ mouse.. J Appl Physiol. 2005 Dec;99(6):2379-87. Tucker JM, Murphy JT, Kisiel N, Diegelman P, Barbour KW, Davis C, Medda M, Alhonen L, Janne J, Kramer DL, Porter CW, Berger FG. Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase.. Cancer Res. 2005 Jun 15;65(12):5390-8. Mehl KA, Davis JM, Clements JM, Berger FG, Pena MM, Carson JA. Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice. J Appl Physiol. 2005 Jun;98(6):2219-25. Miller-Lotan R, Herskowitz Y, Kalet-Litman S, Nakhoul F, Aronson D, Zoabi R, Asaf R, Ben-Izhak O, Sabo E, Lim SK, Baumann H, Berger FG, Levy AP. Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus. Diabetes Metab Res Rev. 2005. Arredouani MS, Kasran A, Vanoirbeek JA, Berger FG, Baumann H, Ceuppens JL. Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo. Immunology. 2005 Feb;114(2):263-71 Murphy JT, Tucker JM, Davis C, Berger FG. Raltitrexed Increases Tumorigenesis as a Single Agent Yet Exhibits Anti-Tumor Synergy with 5-Fluorouracil in Apc(Min/+) Mice(1). Cancer Biol Ther. 2004 Nov 2;3(11) Berger FG. The interleukin-6 gene: a susceptibility factor that may contribute to racial and ethnic disparities in breast cancer mortality. Breast Cancer Res Treat. 2004 Dec;88(3):281-5. Berger SH, Berger FG, Lebioda L. Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase. Biochim Biophys Acta. 2004 Jan 14;1696(1):15-22. Forsthoefel AM, Pena MM, Xing YY, Rafique Z, Berger FG. Structural determinants for the intracellular degradation of human thymidylate synthase. Biochemistry. 2004 Feb 24;43(7):1972-9. Hochepied T, Berger FG, Baumann H, Libert C.alpha(1)-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine Growth Factor Rev. 2003 Feb;14(1):25-34. Yang F, Haile DJ, Berger FG, Herbert DC, Van Beveren E, Ghio AJ. Haptoglobin reduces lung injury associated with exposure to blood. Am J Physiol Lung Cell Mol Physiol. 2003 Feb;284(2):L402-9. Barbour KW, Wei F, Brannan C, Flotte TR, Baumann H, Berger FG. The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure. Genomics. 2002 Nov;80(5):515-22. Tolosano E, Fagoonee S, Hirsch E, Berger FG, Baumann H, Silengo L, Altruda F. Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. Blood. 2002 Dec 1;100(12):4201-8. Tucker JM, Davis C, Kitchens ME, Bunni MA, Priest DG, Spencer HT, Berger FG. Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice. Cancer Lett. 2002 Dec 10;187(1-2):153-62. Hochepied T, Wullaert A, Berger FG, Baumann H, Brouckaert P, Steidler L, Libert C. Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis. Gut. 2002 Sep;51(3):398-404. Barbour KW, Goodwin RL, Guillonneau F, Wang Y, Baumann H, Berger FG. Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop. Mol Biol Evol. 2002 May;19(5):718-27. Wang Y, Kinzie E, Berger FG, Lim SK, Baumann H. Haptoglobin, an inflammation-inducible plasma protein. Redox Rep. 2001;6(6):379-85. Barbour KW, Davis T, White A, Baumann H, Berger FG. Haptoglobin, inflammation, and tumorigenesis in the MIN mouse. Redox Rep. 2001;6(6):366-8. Barker C, Barbour KW, Berger FG, Hajduk SL. Activity of human trypanosome lytic factor in mice. Mol Biochem Parasitol. 2001 Oct;117(2):129-36. Barker C, Barbour KW, Berger FG, Hajduk SL. Activity of human trypanosome lytic factor in mice. Mol Biochem Parasitol. 2001 Oct;117(2):129-36. Shaw D, Berger FG, Spencer HT. Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells. Hum Gene Ther. 2001 Jan 1;12(1):51-9. Hochepied T, Van Molle W, Berger FG, Baumann H, Libert C. Involvement of the acute phase protein alpha 1-acid glycoprotein in nonspecific resistance to a lethal gram-negative infection. J Biol Chem. 2000 May 19;275(20):14903-9. Fantz C, Shaw D, Jennings W, Forsthoefel A, Kitchens M, Phan J, Minor W, Lebioda L, Berger FG, Spencer HT. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254. Mol Pharmacol. 2000 Feb;57(2):359-66. Kitchens ME, Forsthoefel AM, Barbour KW, Spencer HT, Berger FG. Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability. Mol Pharmacol. 1999 Nov;56(5):1063-70. Persson K, Heby O, Berger FG. The functional intronless S-adenosylmethionine decarboxylase gene of the mouse (Amd-2) is linked to the ornithine decarboxylase gene(Odc) on chromosome 12 and is present in distantly related species of the genus Mus. Mamm Genome. 1999 Aug;10(8):784-8. Libert C, Hochepied T, Berger FG, Baumann H, Fiers W, Brouckaert P. High-level constitutive expression of alpha 1-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice. Transgenic Res. 1998 Nov;7(6):429-35. Kitchens ME, Forsthoefel AM, Rafique Z, Spencer HT, Berger FG. Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation. J Biol Chem. 1999 Apr 30;274(18):12544-7. Singh N, Berger FG. Evolution of a mammalian promoter through changes in patterns of transcription factor binding J Mol Evol. 1999 Feb;48(2):252.

Recent Publications:

Huntoon KM, Wang Y, Eppolito CA, Barbour KW, Berger FG, Shrikant PA, Baumann H.

The acute phase protein haptoglobin regulates host immunity.

J Leukoc Biol. 2008 Apr 24. [Epub ahead of print]

Misra S, Obeid LM, Hannun YA, Minamisawa S, Berger FG, Markwald RR, Toole BP, Ghatak S.

Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.

J Biol Chem. 2008 May 23;283(21):14335-44. Epub 2008 Mar 7.

Kwon IK, Schoenlein PV, Delk J, Liu K, Thangaraju M, Dulin NO, Ganapathy V, Berger FG, Browning DD.

Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis.

Cancer. 2008 Apr 1;112(7):1462-70.

Baltgalvis KA, Berger FG, Peña MM, Davis JM, Carson JA.

Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps.

J Appl Physiol. 2008 Apr;104(4):1137-43. Epub 2008 Jan 31.

Baltgalvis KA, Berger FG, Pena MM, Davis JM, Muga SJ, Carson JA.

Interleukin-6 and cachexia in ApcMin/+ mice.

Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R393-401. Epub 2007 Dec 5.

Barbour KW and Berger FG. Cell Death in response to antimetabolites directed at thymidylate synthase. Cancer Chemotherapy and Pharmacolgy. 2007. Cancer Chemother Pharmacol. 2007 Mar 30; [Epub ahead of print].

Berger FG and Berger SH. Thymidylate Synthase as a Chemotherapeutic Drug Target: Where Are We after Fifty Years?
Cancer Biol Ther. 2006 Sep 13;5(9):1238-1241.

You S, Ohmori M, Pena MM, Nassri B, Quiton J, Al-Assad ZA, Liu L, Wood PA, Berger SH, Liu Z, Wyatt MD, Price RL, Berger FG, Hrushesky WJ. Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol. 2006 Jun;87(3):227-36.

Pena MM, Xing YY, Koli S, Berger FG. Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase. Biochem J. 2005 Feb 15;394(Pt 1):355-63.

Mehl KA, Davis JM, Berger FG, Carson JA. Myofiber degeneration/regeneration is induced in the cachectic ApcMin/+ mouse.. J Appl Physiol. 2005 Dec;99(6):2379-87.

Tucker JM, Murphy JT, Kisiel N, Diegelman P, Barbour KW, Davis C, Medda M, Alhonen L, Janne J, Kramer DL, Porter CW, Berger FG.
Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase.. Cancer Res. 2005 Jun 15;65(12):5390-8.

Mehl KA, Davis JM, Clements JM, Berger FG, Pena MM, Carson JA. Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice. J Appl Physiol. 2005 Jun;98(6):2219-25.

Miller-Lotan R, Herskowitz Y, Kalet-Litman S, Nakhoul F, Aronson D, Zoabi R, Asaf R, Ben-Izhak O, Sabo E, Lim SK, Baumann H, Berger FG, Levy AP. Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus. Diabetes Metab Res Rev. 2005.

Arredouani MS, Kasran A, Vanoirbeek JA, Berger FG, Baumann H, Ceuppens JL. Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo. Immunology. 2005 Feb;114(2):263-71

Murphy JT, Tucker JM, Davis C, Berger FG. Raltitrexed Increases Tumorigenesis as a Single Agent Yet Exhibits Anti-Tumor Synergy with 5-Fluorouracil in Apc(Min/+) Mice(1).
Cancer Biol Ther. 2004 Nov 2;3(11)

Berger FG. The interleukin-6 gene: a susceptibility factor that may contribute to racial and ethnic disparities in breast cancer mortality.
Breast Cancer Res Treat. 2004 Dec;88(3):281-5.

Berger SH, Berger FG, Lebioda L. Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase. Biochim Biophys Acta. 2004 Jan 14;1696(1):15-22.

Forsthoefel AM, Pena MM, Xing YY, Rafique Z, Berger FG. Structural determinants for the intracellular degradation of human thymidylate synthase. Biochemistry. 2004 Feb 24;43(7):1972-9.

Hochepied T, Berger FG, Baumann H, Libert C.alpha(1)-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine Growth Factor Rev. 2003 Feb;14(1):25-34.

Yang F, Haile DJ, Berger FG, Herbert DC, Van Beveren E, Ghio AJ. Haptoglobin reduces lung injury associated with exposure to blood. Am J Physiol Lung Cell Mol Physiol. 2003 Feb;284(2):L402-9.

Barbour KW, Wei F, Brannan C, Flotte TR, Baumann H, Berger FG. The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure. Genomics. 2002 Nov;80(5):515-22.

Tolosano E, Fagoonee S, Hirsch E, Berger FG, Baumann H, Silengo L, Altruda F. Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis. Blood. 2002 Dec 1;100(12):4201-8.

Tucker JM, Davis C, Kitchens ME, Bunni MA, Priest DG, Spencer HT, Berger FG. Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice.
Cancer Lett. 2002 Dec 10;187(1-2):153-62.

Hochepied T, Wullaert A, Berger FG, Baumann H, Brouckaert P, Steidler L, Libert C. Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.
Gut. 2002 Sep;51(3):398-404.

Barbour KW, Goodwin RL, Guillonneau F, Wang Y, Baumann H, Berger FG. Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center
loop. Mol Biol Evol. 2002 May;19(5):718-27.

Wang Y, Kinzie E, Berger FG, Lim SK, Baumann H. Haptoglobin, an inflammation-inducible plasma protein.
Redox Rep. 2001;6(6):379-85.

Barbour KW, Davis T, White A, Baumann H, Berger FG. Haptoglobin, inflammation, and tumorigenesis in the MIN mouse. Redox Rep. 2001;6(6):366-8.
Barker C, Barbour KW, Berger FG, Hajduk SL. Activity of human trypanosome lytic factor in mice.
Mol Biochem Parasitol. 2001 Oct;117(2):129-36.

Barker C, Barbour KW, Berger FG, Hajduk SL. Activity of human trypanosome lytic factor in mice.
Mol Biochem Parasitol. 2001 Oct;117(2):129-36.

Shaw D, Berger FG, Spencer HT. Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells. Hum Gene Ther. 2001 Jan 1;12(1):51-9.

Hochepied T, Van Molle W, Berger FG, Baumann H, Libert C. Involvement of the acute phase protein alpha 1-acid glycoprotein in nonspecific resistance to a lethal gram-negative infection. J Biol Chem. 2000 May 19;275(20):14903-9.

Fantz C, Shaw D, Jennings W, Forsthoefel A, Kitchens M, Phan J, Minor W, Lebioda L, Berger FG, Spencer HT. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Mol Pharmacol. 2000 Feb;57(2):359-66.

Kitchens ME, Forsthoefel AM, Barbour KW, Spencer HT, Berger FG. Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability. Mol Pharmacol. 1999 Nov;56(5):1063-70.

Persson K, Heby O, Berger FG. The functional intronless S-adenosylmethionine decarboxylase gene of the mouse (Amd-2) is linked to the ornithine decarboxylase gene(Odc) on chromosome 12 and is present in distantly related species of the genus Mus. Mamm Genome. 1999 Aug;10(8):784-8.

Libert C, Hochepied T, Berger FG, Baumann H, Fiers W, Brouckaert P. High-level constitutive expression of alpha 1-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice. Transgenic Res. 1998 Nov;7(6):429-35.

Kitchens ME, Forsthoefel AM, Rafique Z, Spencer HT, Berger FG. Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation. J Biol Chem. 1999 Apr 30;274(18):12544-7.

Singh N, Berger FG. Evolution of a mammalian promoter through changes in patterns of transcription factor binding
J Mol Evol. 1999 Feb;48(2):252.