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Decreased intestinal polyp multiplicity is
related to exercise mode and gender in ApcMin/+ mic.
Mehl KA, Davis JM, Clements JM, Berger FG, Pena MM, Carson JA.
Dept. of Exercise Science, University of South Carolina, 1300 Wheat
Street, Columbia, SC 29208, USA.
Moderate-intensity
treadmill running can alter male Apc(Min/+) mouse polyp formation. This
purpose of this study was to examine whether exercise mode
differentially affects Apc(Min/+) mouse intestinal polyp development in
male and female mice. Male and female Apc(Min/+) mice were randomly
assigned to control, treadmill (18 m/min; 60 min/day; 6 days/wk), or
voluntary wheel running (24-h access) groups. Nine weeks of training
decreased total intestinal polyps by 29% in male treadmill runners (66
+/- 9; P = 0.038) compared with male controls (93 +/- 7). The number of
large polyps (>/=1-mm diameter) were also reduced by 38% in male
treadmill runners (49 +/- 6; P = 0.005) compared with male controls (79
+/- 6). Treadmill running in female Apc(Min/+) mice and wheel running
in both genders did not affect polyp number or size. Spleen weight
decreased in male treadmill runners (91 +/- 9 mg; P = 0.011) and wheel
runners (75 +/- 6 mg; P = 0.004) compared with controls (141 +/- 13
mg). Plasma IL-6 was reduced by 96% in male treadmill runners (1.2 +/-
0.6 pg/ml) and 78% in male wheel runners (6.6 +/- 3.3 pg/ml) compared
with control mice (27.9 +/- 2.8 pg/ml; P < 0.05). Female mice
responded similarly with an 86% decrease in plasma IL-6 with treadmill
running (3.2 +/- 1.2 pg/ml) and 90% decrease with wheel running (2.9
+/- 2.0 pg/ml) compared with control mice (21.1 +/- 5.3 pg/ml; P <
0.05). The crypt depth-to-villus height ratio in the intestine, an
indirect marker of intestinal inflammation, decreased by 21 (P = 0.024)
and 24% (P = 0.029), respectively, in male and female treadmill runners
but not wheel runners. Physical activity-induced attenuation of
intestinal polyp number and size is dependent on exercise mode and
differs between genders. The modulation of systemic and intestinal
inflammation may also depend on exercise mode.
PMID: 15894538 [PubMed - in process]
PubMed
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