Welcome
to the Berger Lab!
Immunology. 2005
Feb;114(2):263-71
Haptoglobin dampens endotoxin-induced inflammatory
effects both in vitro and in vivo.
Arredouani MS, Kasran A, Vanoirbeek JA, Berger FG, Baumann H,
Ceuppens JL.
Laboratory
for Experimental Immunology, Gasthuisberg University Hospital, Catholic
University of Leuven, Leuven, Belgium. marredou@hsph.harvard.edu
We
report that haptoglobin, an acute-phase protein produced by liver cells
in response to interleukin-6 (IL-6), can modulate the inflammatory
response induced by endotoxins. We provide evidence that haptoglobin
has the ability to selectively antagonize lipopolysaccharide (LPS)
effects in vitro by suppressing monocyte production of tumour necrosis
factor-alpha, IL-10 and IL-12, while it fails to inhibit the production
of IL-6, IL-8 and IL-1 receptor antagonist. In two animal models of
LPS-induced bronchopulmonary hyperreactivity and endotoxic shock,
haptoglobin knockout mice were more sensitive to LPS effects compared
to their wild-type counterparts. The present data suggest that
haptoglobin regulates monocyte activation following LPS stimulation.
The increase in haptoglobin levels during an acute-phase reaction may
generate a feedback effect which dampens the severity of cytokine
release and protects against endotoxin-induced effects.
PubMed
link
Back
to Biology Home Page
Back
to Frank Berger Home Page
Back
to Berger Lab Home Page