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College of Arts & Sciences
Department of Biological Sciences

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Deanna Smith

Head, MCDB
Department of Biology
University of South Carolina

Office: CLS 607
Phone Number: 803 777 3020
Website: Smith lab website
Deanna S. Smith

Molecular motors carry out vital functions in all eukaryotic cells. One of these, Cytoplasmic Dynein, is critical during mitosis, migration and cellular trafficking events. We are characterizing several signaling pathways that impinge on dynein function. Our current focus is on their importance in the adult mammalian nervous system and during colon carcinogenesis in mammals.


Gao FJ, Shi L, Hines T, Hebbar S, Neufeld KL, Smith DS. (2017). Insulin signaling regulates a functional interaction between Adenomatous Polyposis Coli (APC) and cytoplasmic dynein. Mol Biol Cell. Jan 5 [Epub ahead of print] PMID: 28057765.

Gao FJ, Hebbar S, Gao XA, Alexander M, Pandey JP, Walla MD, Cotham WE, King SJ, Smith DS (2015). GSK-3β Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility. Traffic. 2015 Sep;16(9):941-61. PMID: 26010407 Free PMC Article

Pandey JP, Smith DS (2011). A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons. (2011)..J Neurosci. Nov 23;31(47):17207-19. PMID: 22114287.

Hebbar S, Mesngon MT, Guillotte AM, Desai B, Ayala R, Smith DS. 2008. Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells. Journal of Cell Biology. Sep 22;182(6):1063-71.

Hebbar S, Guillotte AM, Mesngon MT, Zhou Q, Wynshaw-Boris A, Smith DS.. 2008. Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli gene. Developmental Neuroscience. 30(1-3):157-70.

Mesngon MT, Tarricone C, Hebbar S, Guillotte AM, Schmitt EW, Lanier L, Musacchio A, King SJ, Smith DS. . 2006. Regulation of cytoplasmic dynein ATPase by Lis1. Journal of Neuroscience. Feb 15;26(7):2132-9.

D. Smith. 2003. Cdk5 in neuroskeletal dynamics. Neurosignals. Sep-Oct;12(4-5):239-51.

Smith DS, Tsai LH.. 2002. Cdk5 behind the wheel: a role in trafficking and transport?. Trends in Cell Biology. Jan;12(1):28-36.

Smith DS, Greer PL, Tsai LH.. 2001. Cdk5 on the brain. Cell Growth and Differentiation. Jun;12(6):277-83.

Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH. 2000. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. Dec;28(3):697-711.

Smith DS, Leone G, DeGregori J, Ahmed MN, Qumsiyeh MB, Nevins JR.. 2000. Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway. Cell Growth and Differentiation. Dec;11(12):625-33.

Smith DS, Niethammer M, Ayala R, Zhou Y, Gambello MJ, Wynshaw-Boris A, Tsai LH. 2000. Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1. Nature Cell Biology. Nov;2(11):767-75.

Hess DT, Smith DS, Patterson SI, Kahn RA, Skene JH, Norden JJ. 1999. Rapid arrest of axon elongation by brefeldin A: a role for the small GTP-binding protein ARF in neuronal growth cones. Journal of Neurobiology. Jan;38(1):105-15.;2-M/abstract

Smith DS, Skene JH. 1997. A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth. Journal of Neuroscience. Jan 15;17(2):646-58.

Hess DT, Patterson SI, Smith DS, Skene JH. 1993. Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide. Nature. Dec 9;366(6455):562-5.