Dept. of Biological Sciences

Nawin C. Mishra

Distinguished Professor Emeritus of Biological Sciences
Ph.D., 1967, McMaster University
803-777-5938
mishra@biol.sc.edu

Genetics and Biochemistry of Nucleic Acids in Eukaryotes

NAWIN C. MISHRA, PhD, is an Emeritus Professor of Molecular Genetics and Genomics at the Department of Biological Sciences at the University of South Carolina. He received his Ph. D from the McMaster University and Postdoctoral training with the late Nobel laureate Professor E. L. Tatum at the Rockefeller University. He initiated the gene transfer experiments in fungi With Tatum at the Rockefeller University (1967-1973). Later he worked on various aspects of gene transfer and the characterization of nuclease and DNA polymerase mutants with altered exonuclease activity in eukaryotes

Professor Mishra has served as a scientific consultant to the FAO of the United Nations, as Chairman of the Program Committee of the Genetics Society of America, and on the review panel of the Human Genome Project for the United States DOE. He has been elected Fellow of the American Association for Advancement of Science since 1986. He has published several articles in prominent research journals, including Nature, the Proceedings of the United States National Academy of Sciences, and Genetics. He has also published two books: The Molecular Biology of Nucleases (two editions of this book ) and Introduction to Proteomics (with a Foreword by Nobel laureate Professor Gunter Blobel), both published by John Wiley & Sons of New York.

Selected Publications:

Mishra NC, Threlkeld SFH. 1967. Variation in expression of rg mutants in Neurospora. Genetics 55, 113-121.

Mishra NC, Threlkeld SFH. 1969. Genetic studies in Eudorina elegans. Genetical Research. 11, 21-31.

Mishra NC. 1971. Heterokaryosis in Neurospora. Genetics 67, 55-59.

Mishra, NC, Tatum EL. 1970. Phosphoglucose mutants of Neurospora and their relation to morphology Proc. Natl. Acad Sciences USA. 70, 3875-3879.

Mishra NC, Tatum EL. 1972. Effect of l-sorbose on polysaccharide synthetases of Neurospora. Proc. Natl. Acad. Sci USA 69, 313-317.

Mishra NC, Szabo G, Tatum EL. 1973. In Role of RNA in Reproduction & Development. North Holland Publisher Amsterdam. 259-268.

Mishra NC, Tatum EL. 1973. Non Mendelian inheritance of DNA-induced inositol independence in Neurospora. Proc.Natl. Acad.Sciences USA 70, 3875-3879.

Scott WA, Mishra NC, Tatum EL. 1973. Biochemical Genetics of Morphogenesis in Neurospora. Brookhaven Symposia in Biology 24, 1-18.

Mishra NC. 1976. Episome-like behaviour of donor DNA in transformed strains of Neurospora. Nature (London) 264, 251-253.

Mishra NC. 1977. Gene transfer Experiments in Neurospora . Brook Haven Symposium in Biology 29,161-165.

Mishra NC. 1977. DNA mediated Genetic Changes in Neurospora. Journal of Gen. Microbiol. 113, 255-259.

Mishra NC. 1977. DNA induced Genetic changes in Neurospora. 177-183. in Modern trends in Transformation & Transfection ( A. Prtoles Lopez , R and Espinosa , M.) North Holland Biomedical Press, Amsterdam.

Mishra NC. 1977. Characterization of new os mutants which originated during genetic transformation in Neurospora . Genetical Research 29, 9-19.

Delange AM, Mishra NC. 1981. Isolation of MMS-and Histidine-Sensitive mutants of Neurospora. Genetics 97, 247-259.

Delange AM, Mishra NC. 1982. Characterization of mutagen-sensitive mutants of Neurospora . Mutation Research 24, 1-13.

Schablik M, Delange AM, Shums AA, Mishra NC. 1982. Construction of a Genomic library of Neurospora. FEMS Microbiology 16, 321-325.

Forsthoefel AM, Mishra NC. 1983. Biochemical Genetics of Neurospora Nucleasese I. Genetical Research Camb. 41, 271- 286.

Mishra NC, Forsthoefel AM. 1983. Biochemical Genetics of Neurospora Nucleases II. Genetical Research Camb. 41, 287-297.

Almasan A, Mishra NC. 1988. Molecular characterization of the mtDNA of a new stopper mutant ER-3 of Neurospora crassa. Genetics 120, 935-945.

Almasan A, Mishra NC. 1990. Characterization of a novel plasmid-like element in Neurospora crassa derived mostly from the mitochondrial DNA. Nuc. Acid Res. 18, 5871-5878.

Almasan A, Mishra NC. 1991. Recombination by sequence repeats with formation of suppressive or residual mtDNA in Neurospora. Proc. Natl. Acad. Sci. USA 88, 7684-7688.

Singleton RW, Mishra NC. 1995. Genetic evidence that aphidicolin inhibits in vivo DNA synthesis in Chinese hamster ovary cells. Mol. Gen. Genet. 247, 462-470.

Mishra NC, Hinnant K, Cason E. 1985. New Ara-C resistant mutant of CHO cells. Genet. Res 45, 265-277.

Vishwanath JK, Mishra NC. 1985. Chinese hamster ovary cell mutant resistant to DNA polymerase inhibitors, I. Mol. Gen. Genet. 200, 393-400.

Vishwanath JK, Mishra NC. 1985. Chinese hamster ovary cell mutant resistant to DNA polymerase inhibitors, II. Mol. Gen. Genet. 200, 400-406.

Mishra NC. 1977. Genetics & Bichemistry of Morphogenesis in Neurospora. Adv. Genetics 19, 341-405.

Mishra NC. 1985. Gene transfer in fungi. Adv. Genetics. 23, 73-178.

Mishra NC. 1991. Genetics and molecular biology of Neurospora. Adv. Genetics 29, 1-66.

Mishra NC. 1995. Molecular Biology of Nucleases. CRC Press, Boca Raton, FL, 312 pages.

Yadav JS, Mishra NC. 1995. Eukaryotic expression vectors. In Biotechnology (ed. By Y. H. Aui, G. Kachatorian), pp 133-180. VCH Publications, New York.

Cooley M, Mishra NC. 2000. Analysis of DNA replication. Current Genetics 38, 256-263.

Mishra NC. 2002. Nucleases : Mol. Biol. & Applications, John Wiley & Sons, NY 372 pages

Mishra NC. 2000 and 2007 Fungal Cells. Encylopedia of Life. McMillan Press for Nature. Page 1-18

Mishra NC. 2010. Introduction to Proteomics with a Forward by Gunter Blobel. John Wiley & Sons , New York

Mishra NC. 2011. Proteomics: Historical Perspectives and Role in Human Health Care. Biopharmacology (in press).

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