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Department of Biological Sciences

Faculty & Staff Directory

Nawin Mishra

Distinguished Professor of Genetics & Genomics
Department of Biology
University of South Carolina

Office: CLS 603
Phone Number: 803-777-5938
Photo of Dr. Mishra

 NAWIN C. MISHRA, PhD, is an Emeritus Professor of Molecular Genetics and Genomics in the Department of Biological Sciences at the University of South Carolina. Dr. Mishra was the member of Biology faculty 1973-2006 first as Associate Professor and later as  Full Professor and Distinguished Professor   He was also involved with Dept of  Microbiology at the USC medical school first as Ad-hoc  Chair of the dept during its formation year and later as adjunct faculty .

He received his B.Sc ( Hons) and M.Sc. from Science college , Patna University  and  his Ph. D from the McMaster University , Hamilton , Ont. Canada in 1967.  He was a merit scholar at the University of Patna and a Fellow of the Government of Ontario at the McMaster University.

He received his Postdoctoral training 1967-1973 with the late Nobel laureate Professor E. L. Tatum at the Rockefeller University in New York;   there he initiated the landmark gene transfer experiments in fungi With Professor Tatum   at the Rockefeller University (1967-1973). At the Rockefeller University he was the recipient of Fellowship for Medical Research of the Jane Coffin Child Fund   of the Yale University.  

Later he worked on various aspects of gene transfer and the   characterization of nuclease and DNA polymerase mutants with altered exonuclease activity in eukaryotes.
Professor Mishra has   served as:

The Chairman of the Program Committee of the Genetics Society of America;

A scientific consultant to the FAO of the United Nations during 1990s;

He also served on the review panel of the Human Genome Project for the United States DOE in mid 1990s.

He has been elected Fellow of the American Association for Advancement of Science since 1986 for the landmark experiment on Gene transfer in Neurospora  with Professor Tatum  .

He is the recipient of Jewels of India / Hind Rattan Award 2014.

Dr. Mishra has given invited lectures in Australia, UK, EU, Russia, Japan , Thailand , India and China . In May 1980 he was sent by the Rockefeller Foundation to Beijing China among a group of 10 US Scientists including several Nobel Laureates to give lectures in a symposium on Molecular Biology : This was the first group of American Scientists sent to China when China became open to west .

Dr. Mishra has trained a large number of Ph.D. students and Post Doctoral fellows that are now members of the faculty in academics and industries in  Americas , India and elsewhere.

Dr. Mishra has successfully  organized two conferences of International nature at the University of South Carolina in Columbia   : First in 1978 for the Genetics Society of America and Second  the Fungal genetics Congress in 1986.

He has published several articles in prominent research journals, including Nature, the Proceedings of the United States National Academy of Sciences, Genetics and Nucleic Acids Research

He has also published two books; First, The Molecular Biology of Nucleases  ( two editions of this book ) and

Second, Introduction to Proteomics with a Foreword by Nobel laureate Professor Gunter Blobel  of the Rockefeller University published by John Wiley of New York . 

Some of his representative publications are cited below:

Mishra , N. C. and Threlkeld  , S. F. H . 1967 Variation in
expression of rg mutants in Neurospora. Genetics 55. 113 –121

Mishra , N.C. and S.F.H. Threlkeld 1969 . Genetic studies
in  Eudorina elegans . Genetical Research .    11, 21-31

Mishra , N. C. 1971 Heterokaryosis in Neurospora  Genetics 67, 55-59.

Mishra , N. C. and _Tatum , E. L. _1970 Phosphoglucose mutants of
Neurospora and their relation to morphology Proc. Natl. Acad Sciences
USA. ,70. 3875-3879.

Mishra , N. C. and _Tatum, E.L_. 1972Effect of l-sorbose on
polysaccharide synthetases of Neurospora Proc. Natl. Acad. Sci USA,
69, 313-317.

Mishra, N C , Szabo , G. , _Tatum , E. L.__ _1973.In role of RNA in
Reproduction & Development . North Holland Publisher Amsterdam .

Mishra N. C. . and  _Tatum E. L_. 1973  Non Mendelian inheritance of
DNA-induced inositol independence in Neurospora. Proc.Natl.
Acad.Sciences USA 70 3875-3879.

Scott , W. A.,  _N. C. Mishra_, _E. L. Tatum_  1973  . _ Biochemical
Genetics of Morphogenesis in Neurospora ._ Brookhaven Symposia in
Biology  24, 1-18.

Mishra N. C. 1976 Episome-like behaviour of donor DNA in transformed
strains of Neurospora.   Nature (London)  264, 251-253.

Mishra . N C. 1977 Gene transfer Experiments in Neurospora .
BrookHaven Symposium in Biology  29,161-165.

Mishra, N. C. 1977 DNA mediated Genetic Changes in Neurospora. Journal
of Gen. Microbiol. 113,255-259.

Mishra, N. C. 1977  DNA induced Genetic changes in Neurospora .
177-183. in Modern trends in Transformation & Transfection  ( A.
Prtoles Lopez , R and Espinosa , M . ) North Holland Biomedical Press
, Amsterdam.

Mishra, N C, 1977. Characterization of new os mutants  which
originated  during genetic transformation in Neurospora . Genetical
Research  camb. 29, 9-19.

Delange, A. M. and N. C. Mishra  1981 Isolation of MMS-and
Histidine –Sensitive mutants of Neurospora.  Genetics  97, 247-259.

 Delange , A. M.  and N. C. Mishra 1982 Characterization of
mutagen –sensitive mutants of Neurospora .    Mutation Research 24, 1-13.

 Schablik , M., A M . . Delange , A.A. Shums and N. C. Mishra
1982. Construction of a Genomic library of Neurospora. FEMS
Microbiology 16, 321-325

Forsthoefel , A.M.  and _N. C. Mishra_  1983. Biochemical
Genetics of Neurospora Nucleasese I  Genetical Research Camb .  41,
271- 286 

N. C. Mishra  and A. M. Forsthoefel 1983 . Biochemical  Genetics of
Neurospora Nucleases II. 41 287-297.

Almasan, A., and Mishra, N. C. 1988.  Molecular characterization of
the mtDNA of a new stopper mutant ER-3 of /Neurospora crassa/.
/Genetics/ 120, 935-945.

Almasan, A., and  Mishra, N. C. 1990.  Characterization of a novel
plasmid-like element in /Neuro­spora crassa/ derived mostly from the
mitochondrial DNA.  /Nuc. Acid Res./ 18:5871-5878.

Almasan, A., and Mishra, N. C. 1991.  Recombination by sequence
repeats with formation of sup­pressive or residual mtDNA in
/Neurospora//Proc. Natl. Acad. Sci. USA/ 88, 7684-7688.*

Singleton, R. W., and Mishra, N. C.  1995.  Genetic evidence that
aphidicolin inhibits /in       vivo/ DNA synthesis in Chinese hamster
ovary cells.  /Mol. Gen. Genet.247, 462-470. *

Mishra, N. C., Hinnant, K., and Cason, E.  1985.  New Ara-C resistant
mutant of CHO cells.Genet. Res 45, 265-277.

Vishwanath, J. K., and Mishra, N. C.  1985a.  Chinese hamster ovary
cell mutant resistant to DNA polymerase inhibitors, I. /Mol. Gen.
Genet./ 200, 393-400.

Vishwanath, J. K., and **Mishra, N. C.  1985b.  Chinese hamster ovary
cell mutant resistant to DNA polymerase inhibitors, II. /Mol. Gen.
Genet./ 200, 400-406. 

Mishra, N.C. 1977 Genetics & Bichemistry of Morphogenesis  in
Neurospora. _Adv. Genetics. 19: 341-405

Mishra, N.C. 1985. Gene transfer in fungi. _Adv. Genetics_. 23:

Mishra, N.C. 1991  Genetics and molecular biology of /Neurospora/.
_Adv. Genetics. 29*: 1-66.

Mishra, N.C. 1995. Molecular Biology of Nucleases*. CRC Press,
Boca Raton, FL, 312 pages.

Yadav, J.S., and N.C. Mishra. 1995. Eukaryotic expression vectors.
In *_Biotechnology (ed. By Y. H. Aui, G. Kachatorian), pp 133-180.
VCH Publications, New York, 937 p.

Cooley, M. and N. C. Mishra 2000   Analysis of DNA replication
Current Genetics 38,256-263.

Mishra, N.C. 2002 **Nucleases : Mol. Biol. & Applications , John
Wiley & Sons , NY  372 pages

Mishra, N.C. 2000. and 2007  Fungal Cells. _Encylopedia of Life_. McMillan
Press for _Nature_.  Page 1-18

Mishra, Nawin C 2010 Introduction to Proteomics  with a Forward by Gunter Blobel John Wiley & Sons , New York

Nawin ,C Mishra 2012 Proteomics : Historical Perspectives and Role in Human Health Care.  Biopharmaceutical Production Technology 489-509.