MICHAEL J. DEWEY

Michael J. Dewey

Associate Professor of Biological Sciences
Director, Peromyscus Stock Center
Ph.D., 1973, University of Pennsylvania
803-777-4132
dewey@biol.sc.edu

Visit the Peromyscus Stock Center
Visit PeroBase (Peromyscus Database)
Dr. Dewey’s Current Vita (.pdf file)

Mouse Genetics

The goal of Dr. Dewey's research is the development and study of genetic models affecting developmental, physiological, and behavioral processes. He employs both laboratory mice (Mus musculus) and deer mice (Peromyscus) which are native to North America. Useful genetic variation is identified through the traditional analyses of naturally occurring variant phenotypes or generated by the more direct approach of transgenic mouse production.

Current projects in the laboratory include

Development of an intermediate density genetic map in deer mice (Peromyscus), relying heavily on PCR based genetic markers. Such a map will considerably enhance the usefulness of deer mice in a variety of research areas including speciation, behavior, and habitat variation.
Investigation of the role of the the serum protein alpha-1-acid glycoprotein in protecting organisms from environmental toxins, and in diminishing the effectiveness of a wide range of pharmaceuticals. Transgenic mice over-expressing alpha-1-acid glycoprotein were developed to study these problems.

Determing the cellular site and mechanism of action of genes whose phenotypes simultaneously affect longevity and the kinetics of blood formation. The experimental approach to these questions involve the production of mosaic mice whose tissues are composed of genetically diverse populations of cells and which are produced by aggregating preimplantation embryos.

Selected Publications: (for full list, see Dr. Dewey’s Current Vita)

Manning E, Crossland J, Dewey MJ, Van Zant G (2001) Genetic homozygosity is associated with increased telomere length in mammalian cells. (Submitted)

Dewey MJ, Dawson WD (2001) Deer mice: the Drosophila of North American mammals. Genesis (in press)

Yoo, S. D., J. W. Holladay, T. K. Fincher, H. Baumann, and M. J. Dewey. 1996. Altered disposition and antidepressant activity of imipramine in transgenic mice with elevated alpha-1-acid glycoprotein. J. Pharmacol. Exp. Ther. 276:918-922.

Bartell, J. G., T. Davis, E. J. Kremer, M. J. Dewey, W. S. Kistler. 1996. Expression of the rat testis-specific histone Hlt gene in transgenic mice. J. Biol. Chem. 271:4046-4054.

Holladay, J. W., M. J. Dewey, S. D. Yoo. 1996. Steady-state kinetics of in transgenic mice with elevated serum AAG levels. Pharmaceutical Res. 13:1313-1316.

Yoo, S. D., J. W. Holladay, T. K. Fincher, and M. J. Dewey. 1995. Rapid analysis of trace levels of imipramine and desipramine by reverse-phase HPLC with UV detection. J. Chromatog. B. 668:338-342.

Robinson, M.L., A. Holmgren, and M.J. Dewey. 1993. Genetic control of ocular morphogenesis: defective lens development associated with ocular anomalies in C57BL/6 mice. Experimental Eye Research 56:7-16.

Miskimins, R., L. W. Knapp, M. J. Dewey, and X. Zhang. 1992. Cell- and tissue-specific expression of a heterologous gene under control of the myelin basic protein gene promoter in transgenic mice. Developmental Brain Research. 65:217-221.

Dewey, M.J., C. Rheaume, F.G. Berger, and H. Baumann. 1990. Inducible and tissue-specific expression of rat alpha-1-acid glycoprotein in transgenic mice. J. Immunol. 144:4392-4398.

Schaefer, C.A. and M.J. Dewey. 1989. Single locus (rol) control of extreme resistance to red cell osmotic lysis: intrinsic mode of gene action. Genetics 121:353-358.

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